Reta Peptide Guide

The following is for INFORMATIONAL Purposes only, this is NOT MEDICAL advice, I AM NOT a medical professional, please consult with your physician before making any changes to your medical treatment plan.

Peptides purchased DIRECT ONLINE are sold for research purposes only, the following information is for REGISTERED researchers.

What is RETATRUTIDE:

Retatrutide is an experimental weight-loss and diabetes treatment drug. It is a
triple hormone receptor agonist, meaning it activates three different metabolic
pathways:

1. GIP (Gastric Inhibitory Polypeptide) receptor
2. GLP-1 (Glucagon-Like Peptide-1) receptor
3. Glucagon receptor

What Conditions MAY Benefit from RETATRUTIDE

1.   Obesity and Overweight
   • Retatrutide has shown significant weight loss effects in clinical trials, with up to 24.2% body weight reduction over 48 weeks.
   • It works by reducing appetite and increasing energy expenditure
     through its triple hormone receptor activation (GLP-1, GIP, and glucagon).
   • Could be beneficial for severe obesity where lifestyle changes and other medications have not been effective.
2. Type 2 Diabetes Mellitus (T2DM)
   • The drug improves blood sugar control by enhancing insulin secretion and reducing glucose production in the liver.
   • Clinical trials indicate improvements in HbA1c levels, a key marker for diabetes management.
3. Metabolic Dysfunction-Associated Steatohepatitis (MASH) /
   Fatty Liver Disease
   • In a clinical trial, Retatrutide reduced liver fat by 82.4% in individuals with obesity and fatty liver disease.
   • Could help prevent progression to cirrhosis or liver failure.
4. Cardiometabolic Disorders
   • Retatrutide has been linked to lower triglycerides and cholesterol
     levels.
   • Could reduce the risk of heart disease, stroke, and other
     cardiovascular conditions in patients with obesity and diabetes.
5. Insulin Resistance and Prediabetes
   • May help people with prediabetes by improving insulin sensitivity and preventing progression to type 2 diabetes.

POTENTIAL Brain – Cognitive Benefits

1.  Appetite Regulation and Food Addiction
   • Retatrutide acts on brain regions that control hunger and satiety, particularly the hypothalamus.
   • GLP-1 and GIP receptors in the brain help reduce cravings, potentially aiding individuals struggling with food addiction or binge eating.
2. Cognitive Function and Neuroprotection
   • GLP-1 receptor agonists (such as semaglutide and liraglutide) have shown neuroprotective effects in studies related to Alzheimer’s and Parkinson’s disease.
   • Retatrutide could enhance memory, learning, and brain plasticity by:
     • Reducing neuroinflammation (a key factor in neurodegenerative diseases).
     • Improving neuronal survival and reducing oxidative stress.
     • Supporting brain energy metabolism through glucagon signaling.
3. Potential Benefits for Alzheimer’s Disease
   • Clinical trials with GLP-1 drugs like semaglutide suggest they may slow
     cognitive decline in Alzheimer’s patients.
   • Retatrutide’s dual GIP/GLP-1 activation could provide even stronger
     neuroprotective effects.
   • It may help clear amyloid-beta plaques and reduce tau protein
     aggregation, which are hallmarks of Alzheimer’s.
4. Mood and Mental Health Benefits
   • GLP-1 receptor agonists have been associated with reduced
     depression and anxiety in animal and human studies.
   • Retatrutide might help improve mood, motivation, and stress resilience by:
     • Modulating dopamine and serotonin levels.
     • Reducing neuroinflammation, which is linked to depression.
     • Supporting better energy metabolism in the brain.
5. Stroke and Brain Injury Recovery
   • Glucagon receptor activation enhances blood flow and metabolism,
     which may aid in stroke recovery.
   • GLP-1 and GIP activation may reduce brain damage following a stroke
     by decreasing inflammation and oxidative stress.

Future Research and Potential Applications

• Given its broad metabolic and neurological effects, Retatrutide could
  be explored for:
  • Neurodegenerative diseases (Alzheimer’s, Parkinson’s)
  • Cognitive enhancement in aging
  • Mood disorders like depression and anxiety
  • Brain injury recovery (stroke, trauma)

Although Retatrutide is still in clinical trials, its effects on weight, metabolism, and inflammation suggest promising benefits for brain health and cognition.

POTENTIAL Clinical Applications

Retatrutide, a triple hormone receptor agonist (GLP-1, GIP, and glucagon), is
primarily being developed for obesity and type 2 diabetes (T2DM). However, its
broad metabolic and systemic effects suggest potential applications in several
other conditions.

1. Obesity and Overweight Management
   • Proven weight loss effects: In clinical trials, Retatrutide led to an average weight reduction of 24.2% over 48 weeks.
   • Targets multiple metabolic pathways: It reduces appetite, increases fat metabolism, and improves energy expenditure.
   • Potential alternative to bariatric surgery: Could be an option for those who do not qualify for or want to avoid surgery.
2. Type 2 Diabetes Mellitus (T2DM) and Prediabetes
   • Lowers blood glucose: By stimulating insulin release and reducing hepatic glucose production.
   • Improves insulin sensitivity: GIP and glucagon receptor activation can enhance insulin action in muscle and fat tissues.
   • Reduces diabetes complications: May help with neuropathy, kidney disease, and cardiovascular risk.
3. Fatty Liver Disease (Metabolic Dysfunction-Associated Steatohepatitis – MASH, formerly NASH)
   • Reduces liver fat: In trials, Retatrutide reduced liver fat by 82.4% in individuals with obesity and fatty liver.
   • May prevent liver fibrosis and cirrhosis: Could help stop the progression of metabolic-associated fatty liver disease (MAFLD) to more severe conditions.
4. Cardiovascular Disease Prevention and Treatment
   • Lowers triglycerides and cholesterol: Could reduce atherosclerosis and heart attack risk.
   • Improves heart function: GLP-1 and glucagon activation may support cardiac metabolism and prevent heart failure progression.
   • Potential for stroke prevention: Reduces risk factors such as obesity, diabetes, and hypertension.
5. Neurodegenerative Diseases (Alzheimer’s, Parkinson’s, Stroke Recovery)
   • Neuroprotective properties: GLP-1 and GIP receptor activation may reduce neuroinflammation and oxidative stress.
   • Potential Alzheimer’s treatment: Studies on GLP-1 drugs (like semaglutide) suggest benefits for cognitive function and plaque reduction.
   • Stroke recovery support: Glucagon receptor activation may enhance blood flow and brain repair mechanisms.
6. Polycystic Ovary Syndrome (PCOS) and Hormonal Disorders
   • Improves insulin resistance: One of the main causes of PCOS, helping with irregular cycles and fertility issues.
   • Reduces weight and inflammation: Benefits women with PCOS struggling with obesity-related symptoms.
7. Anti-Aging and Longevity Research
   • Enhances metabolic flexibility: May slow aging-related metabolic decline.
   • Reduces chronic inflammation: Could help prevent age-related diseases like osteoporosis, cardiovascular disease, and neurodegeneration.
8. Rare and Genetic Metabolic Disorders
   • Prader-Willi Syndrome: Could help control extreme hunger and obesity in individuals with this genetic condition.
   • Lipodystrophy syndromes: May help regulate abnormal fat metabolism.

Future Directions & Ongoing Research

• • Retatrutide is still in clinical trials (Phase 3 TRIUMPH program).
  • Future studies will determine its long-term safety, broader applications, and combination therapies.

If proven safe and effective, Retatrutide could be a revolutionary therapy for
obesity, diabetes, metabolic diseases, and possibly neurodegenerative
conditions.

Does the RealWorld Feedback live up to the “hype” – claimed benefits?

Updated 2–18- 25

• Yes!! in regards to WEIGHTLOSS Retatrutide is easily in the TOP 5 all
  time discussion.
• For those who have plateaued on Sema or Tirzepatide I am getting
  reports that for SOME Retatrutide will break that weight loss plateau.
• I also have reports for some people they had less overall fatigue on
  RETA.
• I will give it the Project Biohacked Stamp of Approval
• In the area of Weightloss, Anti Aging, Neurodegenerative Prevention Reta is well worth considering.
• HOWEVER like with ALL GLPs there are side effects to be aware of!!
  Research carefully, Reta is still in phase 3 clinical trials currently.

Mechanism of Action: How Does VIP Work?

1. Understanding the Three Targeted Receptors

Retatrutide binds to and activates three different G-protein-coupled receptors (GPCRs) that regulate metabolism:

A. GLP-1 Receptor Activation
(Glucagon-Like Peptide-1 Receptor, GLP-1R)

• Primary Locations:
  • Pancreas (β-cells)
  • Brain (hypothalamus, brainstem)
  • Gastrointestinal tract
  • Heart, adipose tissue, liver
• Effects:
  • Enhances insulin secretion (glucose-dependent) → Improves blood sugar control.
  • Inhibits glucagon secretion → Prevents unnecessary hepatic glucose production.
  • Delays gastric emptying → Prolongs satiety, reducing calorie intake.
  • Suppresses appetite via activation of the hypothalamus and brainstem.
  • Neuroprotective effects → May improve cognitive function and reduce neuroinflammation.
  • Cardioprotective effects → Reduces cardiovascular disease risk.

GLP-1 Activation = Blood Sugar Control + Appetite Suppression + Neuroprotection

B. GIP Receptor Activation
(Glucose-Dependent Insulinotropic Polypeptide Receptor, GIPR)

• Primary Locations:
  • Pancreas (β-cells)
  • Adipose tissue
  • Brain (hypothalamus, hippocampus)
  • Gastrointestinal tract
• Effects:
  • Enhances insulin secretion (glucose-dependent) → Supports glucose regulation.
  • Reduces fat accumulation by promoting lipid metabolism.
  • Suppresses inflammation → Improves metabolic health.
  • Enhances brain function → Potential cognitive benefits, neuroprotection.
  • Counteracts GLP-1-induced nausea → Improves tolerability of the drug.

GIP Activation = Insulin Sensitivity + Fat Metabolism + Anti-Inflammation

C. Glucagon Receptor Activation
(Glucagon Receptor, GCGR)

• Primary Locations:
  • Liver
  • Adipose tissue
  • Pancreas (α-cells)
  • Brain (hypothalamus, energy centers)
• Effects:
  • Increases energy expenditure → Boosts resting metabolic rate (RMR).
  • Promotes fat oxidation → Enhances the breakdown of stored fat.
  • Regulates hepatic glucose production → Prevents hypoglycemia.
  • Stimulates thermogenesis → Increases heat production, contributing to weight loss.

Glucagon Activation = Fat Burning + Metabolism Boost + Stable Blood Sugar

2. Synergistic Metabolic Effects of Retatrutide

By simultaneously activating all three pathways, Retatrutide creates a synergistic effect that enhances weight loss, glucose control, and metabolic health beyond what any single or dual-agonist drug can achieve.

A. Weight Loss Mechanism

• GLP-1: Suppresses appetite + delays gastric emptying.
• GIP: Promotes lipid metabolism + counteracts nausea.
• Glucagon: Increases energy expenditure + burns fat.

Net Effect: Retatrutide induces greater and more sustained weight loss than current drugs (24.2% weight reduction in 48 weeks).

B. Glucose Homeostasis and Insulin Sensitivity

• GLP-1 & GIP: Enhance glucose-stimulated insulin secretion → Prevents hyperglycemia.
• Glucagon: Regulates hepatic glucose production → Prevents hypoglycemia.

Net Effect: Improved HbA1c levels, reduced insulin resistance, and lower blood sugar fluctuations.

C. Fatty Liver Reduction (Metabolic Dysfunction-Associated Steatohepatitis – MASH)

• GLP-1 & GIP: Reduce liver inflammation + improve insulin sensitivity.
• Glucagon: Enhances hepatic lipid oxidation → Reduces liver fat.

Net Effect: Retatrutide led to an 82.4% liver fat reduction in trials.

D. Cardiovascular Benefits

• GLP-1: Lowers cholesterol + reduces atherosclerosis risk.
• GIP: Improves endothelial function + anti-inflammatory effects.
• Glucagon: Increases lipid clearance + boosts cardiovascular metabolism.

Net Effect: Lower risk of heart disease, stroke, and hypertension.

E. Neuroprotective & Cognitive Benefits

• GLP-1 & GIP: Reduce neuroinflammation + enhance synaptic plasticity.
• Glucagon: Supports brain metabolism + enhances cognitive function.

Net Effect: Potential benefits in Alzheimer’s, Parkinson’s, and cognitive aging.

1. Key Takeaways:
   • First-in-Class Triple Agonist: Activates GLP-1, GIP, and Glucagon for maximum metabolic benefits.
   • Best Weight Loss in Trials: 24.2% body weight reduction in 48 weeks.
   • Superior Glucose Control: Improves insulin sensitivity and lowers HbA1c.
   • Potential Brain Benefits: Could protect against neurodegenerative diseases.
   • Cardioprotective Effects: Reduces cholesterol, triglycerides, and inflammation.
2. Future Research:
   • Neurodegenerative diseases (Alzheimer’s, Parkinson’s)
   • PCOS & hormonal disorders
   • Longevity & anti-aging therapy

Final Verdict:
If approved, Retatrutide could become the most effective metabolic treatment
available, surpassing semaglutide and tirzepatide in weight loss, diabetes
control, and metabolic enhancement.

Review of Literature: Studies on RETATRUTIDE

1. Phase 2 Clinical Trial on Obesity

A pivotal phase 2 trial evaluated retatrutide’s efficacy and safety in adults with obesity but without diabetes. The study involved 338 participants randomized to receive varying doses of retatrutide (1 mg, 4 mg, 8 mg, or 12 mg) or a placebo,
administered weekly over 48 weeks

1. • Weight Reduction: At 48 weeks, participants receiving the highest dose (12 mg) experienced a mean weight reduction of 24.2% (approximately 26.2 kg or 57.8 lbs). Notably, 83% of participants in this group achieved a weight loss of 15% or more.
     nejm.org
   • Safety Profile: The most common adverse events were gastrointestinal, primarily mild to moderate, occurring mainly during the dose-escalation phase. These findings suggest retatrutide is generally well-tolerated.
     nejm.org
2. Impact on Nonalcoholic Fatty Liver Disease (NAFLD)
   • Liver Fat Reduction: After 48 weeks, those receiving 8 mg and 12 mg doses saw relative liver fat decreases of 81.7% and 86%, respectively. Additionally, liver fat normalized (reduced to less than 5%) in 89% of the 8 mg group and 93% of the 12 mg group.
     vcuhealth.org
   • Weight Loss Correlation: Participants also experienced significant weight loss, averaging 23.8% in the 8 mg group and 25.9% in the 12 mg group over 48 weeks.
     vcuhealth.org
3. Cardiovascular Risk Factor Improvements
   • Lipid Profile Enhancements: At 48 weeks, retatrutide reduced non-HDL cholesterol by up to 26.9% and triglycerides by up to 40.6%. Apolipoprotein B (apoB) levels decreased by up to 24.2%, and apolipoprotein C-III (apoC-III) levels by up to 38%.
     clinicaltrialsarena.com
   • Insulin Resistance Reduction: The NMR-derived lipoprotein insulin resistance score decreased by up to 32.5% at the highest dose, indicating improved insulin sensitivity.
     clinicaltrialsarena.com
4. Comparative Efficacy in Weight Loss
   • Superior Weight Loss: Obese adults treated with retatrutide lost up to 22% of their starting weight after 48 weeks, surpassing the approximately 14% weight loss over 15 months observed with semaglutide, the active ingredient in Ozempic and Wegovy.
     nypost.com

Ongoing Research
Retatrutide is currently undergoing phase 3 trials under the TRIUMPH program, aiming to further evaluate its efficacy and safety in chronic weight management, obstructive sleep apnea, and knee osteoarthritis in individuals with obesity and overweight.
investor.lilly.com
These studies collectively suggest that retatrutide holds significant promise as a multifaceted therapeutic agent for obesity, metabolic disorders, and associated comorbidities.

RESEARCH Suppliers for RETA*:

Important Reminder: Peptides purchased direct online do not come with instructions, they are sold for RESEARCH PURPOSES ONLY – NOT FOR HUMAN CONSUMPTION.

They come in lyophilized powder form and need to be reconstituted at the proper
ratio. To research peptides purchased direct SELF EDUCATION is a MUST.

Online VENDORs will NOT offer guidance on usage, it is a massive liability for them to do so. Suppliers may BLACKLIST individuals who ask about HUMAN USAGE.

IF you are not familiar w/ RESEARCH Peptides I DO not advise purchasing until you have proper education – guidance

For those buying in United States:

ATOMIK LABZ

Only group vetted source for Tirz right now*
Group Discount Code: Biohacked15 (15% off)
https://atomiklabz.com/product/glp-3-10mg/
– Listed as GLP3 on website
– You can check reports to confirm its RETA

Solution Peptides
(2024 1st Place in Voting for Favorite Peptide Supplier)
Group Discount Code: Biohacked15 (15% off)
https://solutionpeptides.net/product/retatrutide-10mg/
– Listed as GLP3 on website
– You can check reports to confirm its RETA

Limitless Life Nootropics
(2023 Top Voted Peptide Supplier by community)
Group Discount Code: Biohacked20 (20% off orders)
https://www.limitlesslifenootropics.com/product/retatrutide-ha/
– Need to have account created to access

For those buying in EU, UK, UAE:
DN Lab Research:
Top VOTED Supplier for UK, EU, Asia & Middle East
Group Discount code: Biohacked15
https://dnlabresearch.com/retatrutide-ha-10mg-2-x-6mg-vials/

For those buying in Canada:
BioSynergen Peptides:
Group Discount code: Biohacked10
https://biosynergen.com/product/retatrutide-5mg/

Important Reminder:
Peptides purchased online are sold FOR RESEARCH PURPOSES ONLY. This means:

• Purchasing direct online for research means you take 100% responsibility for knowing how to SAFELY research.
• Vendors will NOT advise you on how to research these compounds.
  They are sold for research purposes and it is a huge liability and legal risk for vendors to advise on usage. Certain vendors will blacklist those who email asking about human usage.
• Be Prepared: If you are unfamiliar with how to research peptides safely, I highly recommend enrolling in a peptide education course or working with a qualified coach or practitioner.
• Peptide Education course offer & other resources below if interested!

ATOMIK LABZ Ordering LEGEND:

ATOMIK LABZ
Only group vetted source for Tirz right now*
Group Discount Code: Biohacked15 (15% off)
https://atomiklabz.com/product/glp-3-10mg/

RESEARCH DOSING

(Educational Purpose ONLY – Project Biohacked LLC)

Dosing Approaches used in Clinical Trials

Phase 2 Clinical Trial for Type 2 Diabetes
Another phase 2 trial focused on adults with type 2 diabetes assessed the glycemic efficacy and safety of retatrutide over 36 weeks. Participants were randomized to receive once-weekly subcutaneous injections of retatrutide, dulaglutide (1.5 mg), or placebo. The retatrutide dosing regimens included:

• 0.5 mg Group: Consistent 0.5 mg dose weekly.
• 4 mg Groups:
  • With Initial Dose of 2 mg: Started at 2 mg weekly, escalating to 4 mg.
  • Without Escalation: Maintained at 4 mg weekly without escalation.
• 8 mg Groups:
  • Slow Escalation: Initiated at 2 mg weekly, gradually increasing to 8 mg.
  • Fast Escalation: Started at 4 mg weekly, rapidly escalating to 8 mg.
• 12 mg Group: Began with 2 mg weekly, escalating to 12 mg.

The primary endpoint was the change in HbA1c from baseline to 24 weeks, with additional assessments at 36 weeks. Findings indicated significant HbA1c reductions across all retatrutide doses, with the 12 mg group achieving a decrease of 2.02% at 24 weeks. Notably, higher doses were associated with greater weight loss and improved glycemic control.

pubmed.ncbi.nlm.nih.gov

Safety and Tolerability
Across both trials, retatrutide was generally well-tolerated. The most common adverse events were gastrointestinal, primarily mild to moderate, occurring mainly during the dose-escalation phase. These findings suggest that careful dose escalation can enhance tolerability and minimize adverse effects.

Full Dosage Range for RETA:

QUICK TIPS for Researching RETA:

(Informational Purposes only – Project Biohacked LLC)

• Microdose to TEST tolerance if you want to mitigate side effects severity, my personal opinion this is the BEST APPROACH. Give your body time to adjust to the peptide.
• Phase 2 clinical trials went 48 weeks – 12 Months!! My advice is do NOT RUSH increasing the dose, be patient, allow time for your research subject to experience the full benefits that happen SLOWLY overtime with consistent usage.
• The INSULIN resistance benefits and metabolism changes take TIME, if you research subject plateaus then STICK with it, this is commonly reported. Patience and consistency is rewarded!
• Consider SPLIT Dosing – this approach helps to mitigate side effects and keep levels more level compared to ONCE a week dosing which results in a large spike then decline. Dosing 2-3x per week at LOWER doses keeps the peak spike lower and levels more consistent which MAY reduce side effects for research subject.
• Ex. Instead of 1mg 1x per week, split dosing would be 500mcg 2x per week (every 3rd day)
• THERE is NO set in stone split dosing protocol this is purely anecdotal and up to the researcher to find what works BEST.

Peptides that MAY Stack Well With RETA:

1. NAD+ (Nicotinamide Adenine Dinucleotide) – Cellular Energy & Longevity

Synergy: Enhances mitochondrial function and energy production, counteracting potential fatigue from calorie restriction.

Potential Benefits:

• • Boosts ATP production & mitochondrial efficiency
  • Enhances metabolic flexibility & fat oxidation
  • Supports brain function & cognitive clarity
  • Slows down cellular aging & enhances recovery

2. MOTS-c – Mitochondrial Peptide for Fat Oxidation

Synergy: Works at the cellular level to enhance metabolism & endurance.

Potential Benefits:

• • Increases energy production & mitochondrial biogenesis
  • Boosts fat metabolism & insulin sensitivity
  • Enhances endurance & reduces metabolic slowdown
  • Supports longevity & metabolic health

3. AOD 9604 – Fat-Burning Peptide

Synergy: Enhances lipolysis (fat breakdown) without affecting blood sugar.

Potential Benefits:

• • Speeds up stubborn fat loss (visceral & subcutaneous fat)
  • Does not impact insulin or glucose levels
  • Supports joint & cartilage repair
  • Improves recovery from exercise

4. Tesamorelin – Growth Hormone Stimulating Peptide

Synergy: Increases growth hormone (GH) secretion, enhancing fat loss & muscle retention.

Potential Benefits:

• • Reduces visceral fat & improves lipid metabolism
  • Enhances muscle preservation & growth
  • Boosts IGF-1 levels naturally
  • Improves cognitive function & neuroprotection

5. CJC-1295 + Ipamorelin – Growth Hormone Secretagogues

Synergy: Enhances fat loss, muscle retention, & recovery alongside Retatrutide.

Potential Benefits:

• • Increases natural GH secretion → Boosts fat loss
  • Preserves muscle mass & promotes lean body composition
  • Supports deep sleep & anti-aging benefits
  • Improves skin, hair, & joint health

6. BPC-157 – Recovery & Gut Health Peptide

Synergy: Counteracts potential gut issues & supports muscle recovery while on Retatrutide.

Potential Benefits:

• • Repairs gut lining & reduces inflammation
  • Supports healing of joints, tendons, & muscles
  • Accelerates recovery from exercise & injuries
  • Reduces oxidative stress & improves tissue regeneration

7. TB-500 – Endurance & Recovery Peptide

Synergy: Enhances muscle recovery & cardiovascular health, making it beneficial for active individuals using Retatrutide.

Potential Benefits:

• • Reduces inflammation & promotes healing
  • Increases endurance & cardiovascular function
  • Prevents muscle loss & supports mobility
  • Enhances overall tissue regeneration

8. LL-37 – Anti-Inflammatory & Gut Healing Peptide

Synergy: Helps reduce systemic inflammation & supports gut health, improving metabolic function.

Potential Benefits:

• • Supports gut microbiome balance & digestion
  • Reduces systemic inflammation & leaky gut
  • Enhances immune function & antimicrobial activity
  • Supports recovery & metabolic function

9. GHK-Cu – Regenerative & Anti-Aging Peptide

Synergy: Complements Retatrutide by improving recovery, skin elasticity, and fat metabolism.

Potential Benefits:

• • Enhances collagen production & skin rejuvenation
  • Boosts hair regrowth & wound healing
  • Reduces inflammation & supports tissue repair
  • May improve metabolic function & fat breakdown

10. Thymosin Alpha-1 – Immune & Metabolic Modulation Peptide

Synergy: Helps optimize immune function & reduce inflammation, which supports overall metabolic health.

Potential Benefits:

• • Boosts immune response & reduces inflammation
  • Enhances fat metabolism & cellular repair
  • Improves insulin sensitivity & glucose regulation
  • Supports overall metabolic function & longevity

Best Peptide Stack Combinations

For Max Fat Loss:
AOD 9604 + Tesamorelin + MOTS-c + NAD+

For Muscle Retention & Recovery:
CJC-1295/Ipamorelin + TB-500 + BPC-157 + GHK-Cu

For Metabolic Health & Anti-Inflammation:
LL-37 + Thymosin Alpha-1 + NAD+

For Longevity & Anti-Aging:
GHK-Cu + NAD+ + MOTS-c

Medical Disclaimer:
The information provided about peptides is for educational purposes only and should not be considered medical advice. Peptide therapy is not approved by all regulatory agencies and may be considered experimental in some regions. Always consult a licensed healthcare professional before starting any peptide treatment to determine its safety, efficacy, and appropriateness for your specific health condition. Use of peptides should be supervised by qualified medical personnel, and individuals should be aware of potential risks, side effects, and contraindications. This content does not replace professional medical consultation or diagnosis.

Side Effects and Contraindications of Retatrutide

Common Side Effects
The most frequently reported adverse events in retatrutide studies are gastrointestinal in nature. These side effects are generally dose-dependent and range from mild to moderate in severity. They typically occur during the dose-escalation phase and may diminish over time. Key gastrointestinal side effects include:

• Nausea: A common initial response, often subsiding as the body adjusts to the medication.
• Diarrhea: Reported by some participants, usually mild and transient.
• Constipation: Observed in certain cases, manageable with dietary adjustments.
• Vomiting: Less frequent but noted, particularly at higher doses.

Anecdotal Reports

• Increased Anxiety from elevated HR
• Trouble Sleeping

In a phase 2 clinical trial, these gastrointestinal events were the most prevalent adverse effects among retatrutide recipients. The study noted that these events were dose-related and mostly mild to moderate in severity.
nejm.org

Other Observed Side Effects

Beyond gastrointestinal issues, other side effects have been documented:

• Cutaneous Hyperesthesia: A condition characterized by increased skin sensitivity. This was observed in some participants and garnered attention due to its uniqueness. biopharmadive.com
• Increased Heart Rate: Dose-dependent elevations in heart rate were recorded, peaking around 24 weeks and declining thereafter. The clinical significance of this finding remains under investigation. nejm.org

Discontinuation Rates

The rate of discontinuation due to adverse events varied with dosage. In the highest dose group, the discontinuation rate was approximately 16%. biopharmadive.com

Potential Contraindications

While retatrutide is still under investigation and lacks comprehensive contraindication data, certain considerations are prudent:

• Severe Gastrointestinal Disorders: Individuals with significant gastrointestinal diseases may experience exacerbated symptoms. thebiostation.com
• Cardiovascular Conditions: Given the observed increase in heart rate, patients with pre-existing heart conditions should exercise caution.
• Hypersensitivity: As with any medication, those with known hypersensitivity to retatrutide or its components should avoid use.

Current Review of Potential CANCER Risks:

As of now, there is no direct evidence linking retatrutide to an increased or decreased risk of cancer. However, insights can be drawn from studies on similar classes of medications, particularly glucagon-like peptide-1 receptor agonists (GLP-1 RAs), which share some mechanistic pathways with retatrutide.

Thyroid Cancer Concerns

Some GLP-1 RAs have been associated with concerns regarding thyroid cancer:

• Medullary Thyroid Carcinoma (MTC): Animal studies have indicated a potential link between GLP-1 RAs and an increased risk of MTC. Consequently, the U.S. Food and Drug Administration (FDA) has issued boxed warnings for certain GLP-1 RAs, advising against their use in individuals with a personal or family history of MTC or multiple endocrine neoplasia syndrome type 2.
  fredhutch.org
• Human Studies: Epidemiological studies have not consistently demonstrated a significant increase in thyroid cancer risk among GLP-1 RA users. A study published in The BMJ reported that GLP-1 RA use was not associated with a substantially increased risk of thyroid cancer over a mean follow-up of 3.9 years.
  bmj.com

Pancreatic Cancer Considerations

The relationship between GLP-1 RAs and pancreatic cancer has been explored:

• Pancreatic Neoplasms: Some analyses have suggested an association between GLP-1 RA use and an increased reporting rate of pancreatic neoplasms.
  frontiersin.org
• Conflicting Evidence: Other studies have found no significant increase in pancreatic cancer risk. For instance, research published in JAMA Network Open indicated that GLP-1 RA use was not associated with an increased risk of pancreatic cancer.
  jamanetwork.com

Kidney Cancer Observations

Emerging data have highlighted potential concerns regarding kidney cancer:

• Increased Risk: A study noted an increased risk of kidney cancer associated with GLP-1 RA use compared to metformin.
  pubmed.ncbi.nlm.nih.gov

Protective Effects Against Obesity-Related Cancers

Conversely, GLP-1 RAs may offer protective benefits:

• Risk Reduction: Research has suggested that GLP-1 RA use is linked to a significantly reduced risk of several obesity-associated cancers, including colorectal, endometrial, and pancreatic cancers, among patients with type 2 diabetes.
  ajmc.com

Conclusion

While retatrutide itself has not been directly associated with cancer risk, data from similar medications indicate a complex relationship between GLP-1 RA use and cancer incidence. Potential risks may include thyroid and kidney cancers, while protective effects against certain obesity-related cancers have also been observed. Given these nuances, it is imperative for individuals to consult healthcare providers to assess the benefits and risks of retatrutide based on personal medical history and risk factors.

Full List of Suppliers I personally VET: 

I know the owners, I know their customer service teams and I WILL STEP in to help with ANY issues with your orders!!

If you love the content and want to support using my affiliate links it’s greatly appreciated and helps me afford the time to make high quality FREE content for the community which I love doing 🙂

But no pressure!! Even if you just support by just giving quality feedback in the group and good vibes thats appreciated too!! 🙂

**ATOMIK Peptides 🇺🇸
(Tirz Research) – 3rd Party Batch Tested
-Full 3rd party testing reports
Use Discount code Biohacked15 (15% off)
https://atomiklabz.com

Solution Peptides 🇺🇸
(2024 1st Place in Voting for Favorite Peptide Supplier!!)
(Reta, Sema, NAD+, Peptides, Vitamins)
-Full 3rd party testing reports and great feedback from community on this supplier.** **
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-Full 3rd party testing reports
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BioSynergen Peptides: 🇨🇦
Tirz Research Stocked
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CosmicNootropic.com
(Cerebrolysin, Cortexin, Peptide Bioregulators)
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https://cosmicnootropic.com

LVLUPhealth.com
*For the BEST Oral Peptide Formulations – GI Healing – BPC157
*Group Discount Code: Biohacked10 10% off
https://lvluphealth.com/en-us

DN Lab Research is fully operational for our **UK/EU and UAE Members!! **
-Full 3rd party testing reports
Discount Code: Biohacked15
https://dnlabresearch.com

Promethean Bioregulators
US Based Peptide Bioregulator supplier:
Group Discount Code: Biohacked10 10% off
https://www.probr.com

About Promethean:

• They have FULL line of CYTOMAX Bioregulators. These are the full strength natural bioregulators that you see being sold at Cosmic, Qi, Profound Health ETC. They are batch tested for purity and have all the quality reports for each product.
• They STOCK and SHIP from the US!! AKA Fast Shipping
• Boxes each contain 20 caps which covers a STANDARD protocol of 2 caps per day for 10 days. Approaches vary depending on individuals health goal/situation/severity.

ATOMIK LABZ & Solution Peptides Ordering LEGEND
On both sites GLPs are under these different names for cautionary reasons

ATOMIK LABZ 🇺🇸
Only group vetted source for Tirz right now*
Group Discount Code: Biohacked15 (15% off)
https://atomiklabz.com

Solution Peptides 🇺🇸
(2024 1st Place in Voting for Favorite Peptide Supplier!!)
(Reta, Sema, NAD+, Peptides, Vitamins)
–Full 3rd party testing reports and great feedback from community on this supplier.** **
Group Discount Code: **Biohacked15 **15% off
https://solutionpeptides.net

If you need help learning how to safely RESEARCH the above compounds:

I am offering a huge discount on my private membership for my DIY Peptide Education course – resource!!

I want everyone to have an affordable education option so for now I am giving a MASSIVE discount on signup for Project Biohacked Membership.

Use discount code: 100off
https://projectbiohacked.com/product/membership/

This reduces signup to just $49.99!!
(Reduced from $149.99)

Membership INCLUDES:

• 250+ Members currently 🙂
• Start to FINISH Peptide Education course w/ video tutorials
• How to Reconstitute
• How to Calculate dosages
• Choosing the right peptides for your goals
• Stacking, Cycling, Rotating, Trouble Shooting Side effects
• Step by Step how to safely utilize peptides — way more than just a ONE TIME course but a massive peptide education resource that’s constantly being updated!!
• Advanced Stacks and Protocols (weight loss, anti-aging, leaky gut, Lyme/mold/CIRS, Injury Repair and MORE!!)
• Peptide Cheat Sheets and DEEP Dive Guides
• Exclusive discounts for preferred vendors
• Built on Private Platform (Mighty Networks) but also has a PRIVATE Members Facebook group
• Simple to use APP — No Facebook censorship!!
• Peptide Bioregulator Course ALMOST FINISHED!!

VIDEO Walkthrough Preview of Course, Content, Platform:

https://youtu.be/6jzgDu1BzQ4?si=2AnahQGcW3J7MUfW

NO hidden catches, NO upsells, Just pure peptide deep dive protocol goodness

$49.99 gets you FULL ACCESS to all content which is built on a private platform (Mighty Networks)

• Simple to USE APP like FB w/out the censorship!!
• YOU CAN CANCEL ANYTIME

Which means for $49.99 you get a full month of access to a MASSIVE amount of deep dive peptide information with protocols and approaches you simply won’t find anywhere else.

At the end of 1 month, you can opt to cancel or continue membership at $14.99 per month ongoing.

So really for less than $50 you can soak up all the content and information, and if at the end of 1 month you feel you don’t need to hang around, then you can cancel — no questions asked.

Bioregulator course coming soon at NO ADDITIONAL CHARGE to current members!!

ANY QUESTIONS? DON’T HESITATE TO ASK!!

Use discount code: 100off
https://projectbiohacked.com/product/membership/

About the Author

Jeff Robinson B.S. Exercise Physiology Human Performance – Project Biohacked LLC

I graduated from Southern CT University in 2011 with a Bachelors Degree in Exercise Physiology Human Performance.

I’ve been health coaching/consulting privately now for 15+ years and have worked with individuals of all ages and health concerns/goals.

Why did I create Project Biohacked?

It is important to me that people understand my WHY. I want people to fully understand what I am trying to do with the Project Biohacked brand.

This is relevant to peptides since they are one of the tools that forever changed my life for the better and restored my hope I could fully recover my health!

My reason WHY has everything to do with my own at times extremely difficult health journey.

 This life has not always been an easy ride for myself, I have experienced levels of suffering with my own health physically and mentally that I wouldn’t wish upon my worst enemy.

I have been able to recover and go on to experience days, months and years feeling good again. Days where I have felt happy, at peace and content with life. Days I have been able to be fully present with loved ones and just enjoy the simple things in life.

READ MORE ABOUT ME & MY MISSION HERE